Benefits of Direct Factor Xa inhibitors over Warfarin
Benefits of Direct Factor Xa inhibitors over Warfarin Introduction Compared to vitamin K antagonists (VKAs), these target-specific drugs have a fixed dosing with no need for international normalized ratio (INR) monitoring, a wider therapeutic index, rapid onset and short half-lives, and few drug and food interactions, so you may not need to take blood tests […]
JAK inhibitors As a New Therapeutic Option
Introduction The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway; involved in many crucial biological roles, including cell differentiation, proliferation, and apoptosis, and immune regulation; it provides a direct mechanism for extracellular factors-regulated gene expression. Current studies on this pathway have been focusing on the inflammatory and neoplastic diseases and related therapy. […]
Tofacitinib the first FDA approved JAK inhibitor
An overview of Tofacitinib, the first FDA approved JAK inhibitor, and its Indications Introduction Tofacitinib is a type of drug known as Janus kinase JAK inhibitor. Tofacitinib is a small molecule, not a protein; therefore, causing the formation of neutralizing anti-drug antibodies related to therapeutic proteins, and immunogenicity is not expected to occur. It works by […]
increase Risk of Developing Diabetes
COVID-19 infection even mild ones may increase Risk of Developing Diabetes A recent study followed people with mild COVID-19 to analyze whether or not they had an increased risk of developing diabetes. As a sway, they also tracked individuals with an acute upper respiratory tract infection (AURI). The researchers concluded that individuals with mild […]
Benefits of lenalidomide in hematological malignancies
Abstract Lenalidomide is an immunomodulatory drug, which has effect against most of the hematological malignancies. Apart from its immunomodulation, it has other properties such as anti-proliferation and anti-angiogenesis. It is not only effective in myeloma and myelodysplastic syndromes, recent studies show its effectiveness on newly diagnosed and relapsed/refractory lymphomas as well. Addition of lenalidomide to […]
Melonama Monday, May Is Melanoma
Melonama Monday, May Is Melanoma Awareness Month It is Good to Know about the Dark Side of the Sun Melonama Skin cancer, including melanoma as well basal and squamous cell carcinomas, is the most common cancer type.The rates of melanoma, the most dangerous form of skin cancer, have been rising for the past few decades.Melanoma […]
Benefits of Crizotinib in Advanced NSCLC
Benefits of Crizotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Abstract: Non-small-cell lung cancer has poor prognosis and low survival rates, providing a strong rationale for the development of new treatment strategies. Advanced non-small cell lung cancer (NSCLC) Patients have few effective treatment options, only about a third of these patients experience tumor shrinkage with standard […]
EGFR-TKI
The Clinical Efficacy of Combinatorial Therapy of EGFR-TKI and Crizotinib in Overcoming MET amplification-mediated Resistance Abstract Treatment of non-small cell lung cancer harboring epidermal growth factor receptor activating mutation with EGFR-TKIs has achieved great success, yet faces the development of acquired resistance as the biggest obstacle to long-period disease remission in the clinic. MET or c-MET gene amplification has […]
Arthritis
World AUTO immune & AUTO inflammatory Arthritis Day This event historically unites thousands of people in 60+ countries worldwide to drive global awareness and education about the Autoimmune and Auto-inflammatory diseases that include inflammatory-driven arthritis. There is no other globally program focused on Autoimmune Arthritis and associated diseases that is as big and has […]
Overview of Thyroid Cancer
Targeted therapies used in the Treatment of Thyroid Cancer Introduction Thyroid cancer is a rare type of cancer that affects the thyroid gland; it might not cause any symptoms at first. But as it progreses, the signs and symptoms get appeared, including swelling in your neck, difficulty swallowing, and voice changes. There are four main types […]