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Nilotinib HCI. H2O

Nilotinib HCI. H2O

IUPAC name:




Molecular Weight:

584.0 g.mol−1

Molecular Formula:



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Mechanism Of Action:

Nilotinib can inhibit the tyrosine kinase activity of the BCR-ABL protein; CML is caused by the BCR-ABL oncogene. Nilotinib can overcome resistance by inhibiting BCR-ABL with higher affinity than imatinib by binding to the ATP-binding site of the BCR-ABL protein.

Nilotinib showed potential use for myeloproliferative diseases like;  chronic myelomonocytic leukemia, and hyper eosinophilic syndrome by representing ability to inhibit TEL-platelet-derived growth factor receptor-beta (TEL-PDGFRbeta), which causes chronic myelomonocytic leukemia, and FIP1-like-1-PDGFRalpha, which causes hyper eosinophilic syndrome. It can also inhibit the c-Kit receptor kinase, like the D816V-mutated variant of KIT, at pharmacologically achievable concentrations, showing potential use in the treatment of mastocytosis, and gastrointestinal stromal tumors.



It is indicated for the treatment of:

  1. Adult patients with newly diagnosed Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.
  2. Adult patients with Ph+ CML in chronic phase and accelerated phase who no longer benefit from, or didn’t tolerate other treatment like imatinib.
  3. Children (ages 1 year and older) with newly diagnosed Ph+ CML in chronic phase.
  4. Children (ages 1 year and older) with chronic phase Ph+ CML or accelerated phase Ph+ CML who:
    1. Are no longer benefiting from treatment with a tyrosine kinase inhibitor medicine, or
    2. Have taken another tyrosine kinase inhibitor medicine and cannot tolerate it.
Category: Oncology
January 20, 2024
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