Benefits of Direct Factor Xa inhibitors over Warfarin
Benefits of Direct Factor Xa inhibitors over Warfarin Introduction Compared to vitamin K antagonists (VKAs), these target-specific drugs have a fixed dosing with no need for international normalized ratio (INR) monitoring, a wider therapeutic index, rapid onset and short half-lives, and few drug and food interactions, so you may not need to take blood tests […]
JAK inhibitors As a New Therapeutic Option
Introduction The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway; involved in many crucial biological roles, including cell differentiation, proliferation, and apoptosis, and immune regulation; it provides a direct mechanism for extracellular factors-regulated gene expression. Current studies on this pathway have been focusing on the inflammatory and neoplastic diseases and related therapy. […]
Tofacitinib the first FDA approved JAK inhibitor
An overview of Tofacitinib, the first FDA approved JAK inhibitor, and its Indications Introduction Tofacitinib is a type of drug known as Janus kinase JAK inhibitor. Tofacitinib is a small molecule, not a protein; therefore, causing the formation of neutralizing anti-drug antibodies related to therapeutic proteins, and immunogenicity is not expected to occur. It works by […]
increase Risk of Developing Diabetes
COVID-19 infection even mild ones may increase Risk of Developing Diabetes A recent study followed people with mild COVID-19 to analyze whether or not they had an increased risk of developing diabetes. As a sway, they also tracked individuals with an acute upper respiratory tract infection (AURI). The researchers concluded that individuals with mild […]
Benefits of lenalidomide in hematological malignancies
Abstract Lenalidomide is an immunomodulatory drug, which has effect against most of the hematological malignancies. Apart from its immunomodulation, it has other properties such as anti-proliferation and anti-angiogenesis. It is not only effective in myeloma and myelodysplastic syndromes, recent studies show its effectiveness on newly diagnosed and relapsed/refractory lymphomas as well. Addition of lenalidomide to […]
Melonama Monday, May Is Melanoma
Melonama Monday, May Is Melanoma Awareness Month It is Good to Know about the Dark Side of the Sun Melonama Skin cancer, including melanoma as well basal and squamous cell carcinomas, is the most common cancer type.The rates of melanoma, the most dangerous form of skin cancer, have been rising for the past few decades.Melanoma […]
Waldenstrom Macroglobulinemia (WM)
Introduction of Waldenstrom Macroglobulinemia (WM) Waldenstrom Macroglobulinemia (WM) is a non-Hodgkin lymphoma (NHL), in which the cancer cells make large amounts of an abnormal protein (called a macroglobulin). Another name for this subtype of NHL cancers is lymphoplasmacytic lymphoma. This condition is a rare indolent B-cell lymphoma that occurs in less than two percent of […]
Graft-versus-Host Disease (GvHD)
Quick Review over Graft-versus-Host Disease (GvHD) Introduction: Graft-versus-Host Disease (GvHD) is a common complication because of a transplantation using donor; this complication occurs when the donor’s immune system (the graft) recognizes the patient’s organs and tissues (the host) as unfamiliar cells that should be destroyed. This complication is triggered by a type of white blood cell […]
Cancer Statistics
Cancer statistics According to the American Cancer Society’s annual estimate of 2021, there will be 1898160 new cases and 608570 deaths caused by that in the United States. In generally, due to improvements in various facets of humans’ lives, including availability of different instruments for diagnosing mortality rate has shrunk from its peak in 1991 […]
Multiple sclerosis (MS)
Quick Review over Multiple sclerosis (MS) Multiple sclerosis (MS) is a lifelong, and often disabling disease which affects the central nervous system (brain and spine). In multiple sclerosis, scattered patches of the protective myelin covering of the nerve fibers in the CNS are damaged or destroyed. This leads to inflammation and loss of myelin which […]