Amyotrophic lateral sclerosis (ALS)
Review over Amyotrophic Lateral Sclerosis (ALS) and the First FDA-Approved Drug for Treatment of ALS: Introduction Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells which control voluntary muscle movement. Patient’s sensory functions or mental faculties doesn’t changed through ALS. ALS is considered as a progressive disease. There is […]
Understanding Type 2 Diabetes and Medications for Management
Type 2 diabetes is a prevalent chronic condition, that affects millions of people worldwide. It occurs when the body cannot effectively use the insulin it produces, leading to elevated blood sugar levels. Proper management of Type 2 diabetes is crucial to prevent complications and improve the quality of life for those diagnosed. In addition […]
Molnupiravir
Molnupiravir may be effective against the omicron sub-variant BA.5 According to a study published in the New England Journal of Medicine on Thursday, a team led by a professor of virology at the University of Tokyo, found that small-molecule antiviral drug molnupiravir curbed virus activity in cultured monkey cells infected with the highly contagious […]
Soft Tissue Sarcoma
Tyrosine kinase inhibitors in Soft Tissue Sarcomas treatment Sarcomas are a group of rare mesenchymal malignant cancers which arise from transformed cells of the mesenchymal connective tissue, and are challenging to be treated. The majority of sarcomas are soft tissue sarcomas (STSs; 75%) and this heterogeneous group of tumors is further comprised of gastrointestinal […]
Dapagliflozin in Patients with Type 2 Diabetes
Benefits of Dapagliflozin When in Patients with Type 2 Diabetes Abstracts Dapagliflozin reduces the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes whether or not they were also taking various cardiovascular (CV) medications. The study that has published in JAMA Cardiology, explored whether the diuretic and antihypertensive effects of dapagliflozin, a sodium-glucose cotransporter […]
Breast Cancer Awareness Month
Breast Cancer Awareness October is Breast Cancer Awareness Month, an annually campaign to raise awareness of this disease.Yet, for many, Breast Cancer Awareness Month is also a difficult reminder of their personal experience with breast cancer and the many patients we have lost to this disease. As of 2020, there were 2.26 million worldwide cases of breast […]
Comprehending Heart Failure and Its Therapeutic Approaches
Comprehending Heart Failure and Its Therapeutic Approaches Introduction to Heart Failure Heart failure is a complex and chronic medical condition that affects millions of individuals worldwide. Despite the term sounding quite severe, it does not mean that the heart has completely ceased to function. Instead, heart failure indicates that the heart is not pumping […]
Role of Direct Factor Xa inhibitors in Cardiovascular Events
Introduction Direct Factor Xa inhibitors are a type of anticoagulant drugs which act by binding selectively and reversibly to the clotting factor Xa. Factor Xa plays an important role in the blood clotting mechanism. When an injury occurred, they forming a mesh to prevent loss of blood. However, clots can form within the body and cause blockages in the veins, arteries, […]
Benefits of Direct Factor Xa inhibitors over Warfarin
Benefits of Direct Factor Xa inhibitors over Warfarin Introduction Compared to vitamin K antagonists (VKAs), these target-specific drugs have a fixed dosing with no need for international normalized ratio (INR) monitoring, a wider therapeutic index, rapid onset and short half-lives, and few drug and food interactions, so you may not need to take blood tests […]
JAK inhibitors As a New Therapeutic Option
Introduction The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway; involved in many crucial biological roles, including cell differentiation, proliferation, and apoptosis, and immune regulation; it provides a direct mechanism for extracellular factors-regulated gene expression. Current studies on this pathway have been focusing on the inflammatory and neoplastic diseases and related therapy. […]