Tofacitinib the first FDA approved JAK inhibitor
An overview of Tofacitinib, the first FDA approved JAK inhibitor, and its Indications Introduction Tofacitinib is a type of drug known as Janus kinase JAK inhibitor. Tofacitinib is a small molecule, not a protein; therefore, causing the formation of neutralizing anti-drug antibodies related to therapeutic proteins, and immunogenicity is not expected to occur. It works by […]
increase Risk of Developing Diabetes
COVID-19 infection even mild ones may increase Risk of Developing Diabetes A recent study followed people with mild COVID-19 to analyze whether or not they had an increased risk of developing diabetes. As a sway, they also tracked individuals with an acute upper respiratory tract infection (AURI). The researchers concluded that individuals with mild […]
Benefits of lenalidomide in hematological malignancies
Abstract Lenalidomide is an immunomodulatory drug, which has effect against most of the hematological malignancies. Apart from its immunomodulation, it has other properties such as anti-proliferation and anti-angiogenesis. It is not only effective in myeloma and myelodysplastic syndromes, recent studies show its effectiveness on newly diagnosed and relapsed/refractory lymphomas as well. Addition of lenalidomide to […]
Melonama Monday, May Is Melanoma
Melonama Monday, May Is Melanoma Awareness Month It is Good to Know about the Dark Side of the Sun Melonama Skin cancer, including melanoma as well basal and squamous cell carcinomas, is the most common cancer type.The rates of melanoma, the most dangerous form of skin cancer, have been rising for the past few decades.Melanoma […]
Benefits of Crizotinib in Advanced NSCLC
Benefits of Crizotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Abstract: Non-small-cell lung cancer has poor prognosis and low survival rates, providing a strong rationale for the development of new treatment strategies. Advanced non-small cell lung cancer (NSCLC) Patients have few effective treatment options, only about a third of these patients experience tumor shrinkage with standard […]
EGFR-TKI
The Clinical Efficacy of Combinatorial Therapy of EGFR-TKI and Crizotinib in Overcoming MET amplification-mediated Resistance Abstract Treatment of non-small cell lung cancer harboring epidermal growth factor receptor activating mutation with EGFR-TKIs has achieved great success, yet faces the development of acquired resistance as the biggest obstacle to long-period disease remission in the clinic. MET or c-MET gene amplification has […]
Cancer Statistics
Cancer statistics According to the American Cancer Society’s annual estimate of 2021, there will be 1898160 new cases and 608570 deaths caused by that in the United States. In generally, due to improvements in various facets of humans’ lives, including availability of different instruments for diagnosing mortality rate has shrunk from its peak in 1991 […]
Multiple sclerosis (MS)
Quick Review over Multiple sclerosis (MS) Multiple sclerosis (MS) is a lifelong, and often disabling disease which affects the central nervous system (brain and spine). In multiple sclerosis, scattered patches of the protective myelin covering of the nerve fibers in the CNS are damaged or destroyed. This leads to inflammation and loss of myelin which […]
Protein Tyrosine Kinases:Their Roles and Their Targeting in Leukemia
Protein tyrosine kinases superfamily definition A large group of enzymes that speeding up protein phosphorylation and controlling multiple signaling incidents are titled as Protein tyrosine kinases, which represents a complicated system and is wrapped up by of 518 members. Based on their ability to phosphorylate either tyrosine or serine and threonine residues, they are classified into two main […]
Disease modifying therapies (DMTs)
Quick Review Over Disease Modifying Therapies (DMTs) For Multiple Sclerosis Introduction: Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the CNS. Although there is no curable options for MS, a number of medications also called, disease modifying therapies, or DMTs, have been approved to treat MS. Permanent damage to the central nervous system can […]