Mechanism Of Action:
Voriconazole is a triazole antifungal agent that works by inhibiting the fungal cytochrome P450 enzyme 14-alpha-lanosterol demethylase1. This enzyme is crucial for the conversion of lanosterol to ergosterol, an essential component of the fungal cell membrane2. By blocking this step, voriconazole disrupts the synthesis of ergosterol, leading to increased membrane permeability and ultimately causing the death of the fungal cell3. This mechanism makes voriconazole effective against a wide range of fungal infections, including those caused by Aspergillus and Candida species.
Indications
Invasive Aspergillosis: Treats serious fungal infections caused by Aspergillus species, often starting in the lungs and spreading to other organs1.
Candidemia: Used for fungal infections in the blood, particularly in non-neutropenic patients (those with normal levels of neutrophils, a type of white blood cell).
Esophageal Candidiasis: Treats yeast infections in the esophagus, which can cause white patches and discomfort2.
Serious Fungal Infections: Effective against infections caused by Fusarium species and Scedosporium apiospermum, especially in patients who do not respond to other treatments.
