Sorafenib tosylate

Sorafenib is a tyrosine kinase inhibitor, Angiogenesis Inhibitor and VEGF inhibitor. It inhibits multiple intracellular (c-CRAF, BRAF and mutant BRAF) and cell surface kinases

IUPAC name:

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

CAS No.

475207-59-1

Molecular Weight:

637g.mol−1

Molecular Formula:

C28H24ClF3N4O6S

Granule:

Available Ready to press

Mechanism Of Action:

Sorafenib has demonstrated decreased tumor cell proliferation in vitro.
It was shown to inhibit multiple intracellular (c-CRAF, BRAF, and mutant BRAF) and cell surface kinases (KIT, FLT-3, RET, RET/PTC, VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR–ß). Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis, and apoptosis.
It also has showed inhibition of tumor growth and decreasing of tumor apoptosis in models of hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), and differentiated thyroid cancer (DTC).

Indication:

The treatment of patients with unresectable hepatocellular carcinoma (HCC)
The treatment of patients with advanced renal cell carcinoma (RCC).
The treatment of patients with locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine treatment.

information

Category: oncology

December 2, 2023

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