Palbociclib

IUPAC name:

6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one

CAS No.

571190-30-2

Molecular Weight:

447.5 g.mol−1

Molecular Formula:

C24H29N7O2

Granule:

Available - Ready to fill

Mechanism Of Action:

Palbociclib is a CDK4/6 inhibitor that acts by binding to the ATP pocket. The CDK4/6 kinase is involved in the G1-S transition, so, inhibition of this step prevents cell cycle in cells in whose this pathway is functioning.

Indication:

It is indicated for hormone receptor positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC), that has spread to other parts of the body; can be used in men and women.

HR+, HER2- is the most common subtype (approximately 60% of all cases) of metastatic breast cancer(mBC).

information

Category: Oncology

January 21, 2024

Lenvatinib Mesylate

Oncology

Cas No: 857890-39-2

Mechanism Of Action: Lenvatinib is classified as a receptor tyrosine kinase (RTK) inhibitor that effectively suppresses the kinase activities of vascular endothelial growth factor (VEGF)

TRAMETINIB DIMETHYL SULFOXIDE

Oncology

Cas No: 1187431-43-1

Mechanism Of Action: Trametinib is identified as a reversible and remarkably selective allosteric inhibitor of MEK1 and MEK2. Through its high-affinity binding to unphosphorylated MEK1

DABRAFENIB MESYLATE

Oncology

Cas No: 1195768-06-9

Mechanism Of Action: Dabrafenib is recognized as a competitive and highly selective inhibitor of BRAF. Its mechanism of action involves binding to the ATP pocket

Abemaciclib

Oncology

Cas No: 1231929-97-7

Mechanism Of Action: Abemaciclib demonstrates high selectivity in inhibiting CDK4 and CDK6 with potent activity in the low nanomolar range. By inhibiting the phosphorylation of

Sacubitril-Valsartan

Cardiovascular

Cas No: 936623-90-4

Mechanism Of Action: Sacubitril/valsartan is a medication that exerts its effects through the dual inhibition of neprilysin, an enzyme responsible for degrading certain peptides, and

Roxadustat

Anti-Anemic

Cas No: 808118-40-3

Mechanism Of Action: Anemia is a common complication of chronic kidney disease that can be caused by reduced production of renal erythropoietin (EPO), functional iron