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Lenalidomide hemihydrate

Lenalidomide Hemihydrate

Lenalidomide hemihydrate

IUPAC name:

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;hydrate

CAS No.

847871-99-2

Molecular Weight:

536.5 g.mol−1

Molecular Formula:

C26H28N6O7

Granule:

Explationtion

Mechanism Of Action:

  1. Exhibits immunomodulatory properties.
  2. Activates and increases number of T cells and NK cells
  3. Increases number of NKT cells
  4. Inhibits pro-inflammatory cytokines (e.g., TNF-a, and IL-6) by monocytes
  5. Inhibits cell proliferation and induces apoptosis of tumor cells in vitro and inhibition of tumor growth in vivo, leading to a decrease in tumor burden.
  6. Inhibits angiogenesis by reducing levels of VEGF, TNF-a, and IL-6.

Indication:

  1. Newly diagnosed multiple myeloma(MM) in patients who have undergone/ or not eligible for autologous stem cell transplantation, and Multiple myeloma in patients who have received at least one prior therapy
  2. Myelodysplastic syndromes(MDS)
  3. Mantle cell lymphoma(MCL)
  4. Follicular lymphoma
information
Category: Oncology
January 21, 2024
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