Mechanism Of Action:

It acts centrally by activating the nuclear factor erythroid 2 related factor 2 (Nrf2) transcriptional pathway, which regulates enzymes that reduce oxidative stress. And may enhance the Nrf2 transcriptional pathway within the CNS, but this is unproven.

Indication:

Dimethyl fumarate is indicated for the treatment of relapsing types of MS including: clinically isolated syndrome (CIS), relapsing-remitting disease, and active secondary progressive disease, in adult patients.