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APIXABAN

APIXABAN

IUPAC name:

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide

CAS No.

503612-47-3

Molecular Weight:

459.5g.mol−1

Molecular Formula:

C25H25N5O4

Granule:

Available-Ready to press

Explationtion

Mechanism Of Action:

It’s a highly selective and reversible direct inhibitor of free and clot-bound factor Xa, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. FXa catalyzes the conversion of prothrombin to thrombin.

Indication:

  1. Prophylaxis of venous thromboembolism following knee or hip replacement surgery
  2. Treatment of Deep Vein Thrombosis (DVT) & Pulmonary Embolism (PE)
  3. Prophylaxis of recurrent DVT and PE
  4. Prophylaxis of stroke and systemic embolism in non-valvular atrial fibrillation and at least one risk factor (such as previous stroke or transient ischemic attack, symptomatic heart failure, diabetes mellitus, hypertension, or age 75 years and over)
information
Category: Cardiovascular
January 21, 2024
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